Fenergan Uses, Dosage and Side Effects - Drugs.com (2023)

generic name: Promethazine(Oral) [pr贸-METH-a-zeen]
Brand names:Fenegano,Fenadoz,Prometegano
drug classes: Antihistamines,Phenothiazine-Antiemetic

Clinically verified byDR. look into the binoculars. Last updated on February 6, 2023.

Phenergan is also found in combination with other drugs such as phenylephrine (Prometh Hydrochloride), codeine (Prometh VC), or dextromethorphan (Promethazine DM).

What is Phenergan?

Phenergan belongs to a group of medicines called phenothiazines. It works by changing the way chemicals work in your brain. Promethazine also acts as an antihistamine. It blocks the effects of the natural chemical histamine in your body.

Phenergan is used to treat allergy symptoms such as itchy, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

Phenergan also prevents motion sickness and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.

Phenergan is not used to treat the symptoms of asthma, pneumonia, or other lower respiratory tract infections.


Stop using Phenergan and call your doctor at once if you experience spasms or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be the first signs of dangerous side effects.Phenergan should not be given to children under the age of 2 years.Phenergan can cause severe breathing problems or death in very young children. Follow your doctor's instructions carefully when giving this medication to a child of any age.

Phenergan can cause side effects that affect your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol, which can increase some of Phenergan's side effects. There are many other medications that can interact with promethazine. Tell your doctor about all prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and medications prescribed by other doctors. Do not start using a new medication without consulting your doctor. Keep a list of all the medications you are taking and show it to any doctor or other healthcare professional treating you.

Before taking this medicine

Phenergan should not be given to children under the age of 2 years. Phenergan can cause severe breathing problems or death in very young children.Follow your doctor's instructions carefully when giving this medication to a child of any age.

You should not take Phenergan if you are allergic to promethazine or similar drugs such as chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, thioridazine, or trifluperazine.

You should not take Fenergan if you have asthma or any other lower respiratory disease.

To make sure Phenergan is safe for you, tell your doctor if you have:

  • asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorders;

  • a sulfite allergy;

  • a history of seizures;

  • a weak immune system (bone marrow suppression);

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  • Glaucoma;

  • enlarged prostate or urinary problems;

  • gastric ulcer or obstruction;

  • heart disease or high blood pressure;

  • liver disease;

  • adrenal tumor (pheochromocytoma);

  • low level of calcium in the blood (hypocalcaemia); any

  • if you have ever had a serious side effect while taking promethazine or any other phenothiazine.

It is not known if Phenergan will affect an unborn baby. Animal testing has shown no effects. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known if promethazine passes into breast milk or if it could affect a nursing baby. Tell your doctor if you're breastfeeding before using Fenergan.

Phenergan Pregnancy and Lactation Precautions (More details)

How should I take Phenergan?

Take Phenergan exactly as your doctor has told you. Follow all directions on the prescription label. Your doctor may occasionally change your dose to ensure you get the best results. Do not take this medication in larger or smaller amounts, or for longer than recommended.

Phenergan is often taken at bedtime or before meals. For motion sickness, Phenergan is usually started within 1 hour of travel. When used for surgery, Phenergan is usually taken the night before surgery.

How often you take Fenergan and when your dose is given depends on the condition being treated.

Measure the liquid medicine with the supplied dosing syringe or with a special measuring spoon or medicine cup. If you do not have a measuring cup, ask your pharmacist for one.

If a child is taking this medication, tell your doctor if the child has any weight changes. Phenergan doses are based on the child's weight and any changes may affect your child's dose.

Call your doctor if your symptoms don't improve or worsen while using Fenergan.

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This drug can cause abnormal results on certain medical tests. Tell any doctor who treats you that you use Phenergan.

Store Phenergan at room temperature away from moisture, heat and light.

Detailed Phenergan dosage information

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for the next scheduled dose. Do not take additional medication to make up for a missed dose.

What happens if I overdose?

See an ambulance or call the poison control center at 1-800-222-1222.

Symptoms of overdose may include overactive reflexes, loss of coordination, severe sleepiness or weakness, fainting, dilated pupils, weak or shallow breathing, or seizures (fits).

what to avoid

This medicine may affect how you think or react. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too quickly from a sitting or lying position as you may experience dizziness. Get up slowly and balance yourself to avoid falling.

Drinking alcohol can increase certain side effects of Phenergan. Do not drink alcohol while taking this medicine.

Avoid sun exposure or tanning beds. Phenergan can easily cause sunburn. Wear protective clothing and sunscreen (SPF 30 or higher) when outdoors.

Phenergan side effects

Get emergency medical help if you have itsigns of an allergic reaction: hives; difficulty breathing; swelling of the face, lips, tongue or throat.

Stop using Phenergan and call your doctor at once if you have:

  • severe drowsiness, weak or shallow breathing;

  • dizziness, as if you are about to pass out;

  • confusion, agitation, hallucinations, nightmares;

  • seizures (convulsions);

  • fast or slow heartbeat;

  • jaundice (yellowing of the skin or eyes);

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  • uncontrolled muscle movements in the face (chewing, smacking your lips, frowning, tongue moving, blinking, or moving your eyes);

  • easy bruising or bleeding (nosebleeds, bleeding gums);

  • sudden weakness or nausea, fever, chills, sore throat, mouth sores, red or swollen gums, difficulty swallowing; any

  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or irregular heartbeat, tremor, feeling like you might pass out.

Side effects such as confusion and severe drowsiness may be more likely in older adults.

Common side effects of Phenergan may include:

  • drowsiness, dizziness;

  • ringing in the ears;

  • double vision;

  • feel nervous;

  • dry mouth; O

  • tiredness, trouble sleeping (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Phenergan side effects (More details)

What other drugs will affect Fenergan?

Cold or allergy medications, tranquilizers, narcotic pain relievers, sleeping pills, muscle relaxants, and medications for seizures, depression, or anxiety can all interact with Fenergan and cause medical problems or increase side effects. Tell your doctor if you use any of these medicines regularly.

Also tell your doctor if you are taking any of the following medicines:

  • litio (Eskalith, Lithobid);

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  • Atropin (Atreza, Sal-Tropine), Belladonna (Donnatal und andere), Benzotropin (Cogentin), Dimenhydrinat (Dramamine), Methscopolamin (Pamine) oder Scopolamin (Transderm-Scop);

  • blood pressure medications such as guanadrel (Hylorel), guanethidine (Ismelin), propranolol (Inderal), and others;

  • an anticoagulant such as warfarin (Coumadin);

  • bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

  • bladder or urine medications such as oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), and others;

  • an MAOI such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam), or methylene blue injection; any

  • medicines used to treat Parkinson's disease, restless legs syndrome or a tumor of the pituitary gland (prolactinoma); any

  • Medicines used to treat stomach ulcers or irritable bowel syndrome, such as dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin and others), mepenzolate (Cantil), or propantheline (Pro-Banthine).

This list is not exhaustive and there are many other drugs that can interact with Phenergan. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and medications that other doctors have prescribed. Do not start taking a new medication without consulting your doctor. Keep a list of all the medications you are taking and show it to any doctor or other healthcare professional treating you.

Interactions with Phenergan drugs (More details)

Where can I get more information?

Remember to keep this and all other medications out of the reach of children, never share your medication with others, and use this medication only for the prescribed indication.

Frequently Asked Questions

  • Combining promethazine with codeine versus high tech promethazine with codeine?
  • How long does promethazine stay in your system?

More on Phenergan (Promethazine)

  • Check the interactions
  • compare alternatives
  • Comments (141)
  • drugs pictures
  • Secondary Effects
  • dosing information
  • Tips for Patients
  • During pregnancy
  • support group
  • Drug Class: Antihistamines
  • breastfeeding

patient resources

  • Advanced Reading
  • Phenergan Injection, Intravenous (Advanced Reading)
  • Phenergan Rectal (Advanced Reading)
  • Phenergan (Promethazine Injection)
  • Phenergan (Promethazine Suppositories)
  • Fenergan (Promethazine Tablets)

Other brands

Prometegano,Fenadoz,Antinaus 50

professional resources

  • Prescribing Information

Related Treatment Guidelines

  • allergic reaction
  • allergic rhinitis
  • Anaphylaxis
  • slight reassurance

More information

Always check with your doctor to ensure that the information presented on this page is appropriate for your personal circumstances.

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